Health Library Cryosurgery for Nonmelanoma Skin CancerFrom Healthwise

Cryosurgery is the process of destroying a skin cancer (lesion) by freezing it with liquid nitrogen. Liquid nitrogen is applied to the lesion using a cotton applicator stick or an aerosol spray.

The skin may first be numbed with a local anesthetic. The liquid nitrogen is applied or sprayed onto the cancer and the immediate surrounding tissue. The application may be repeated. An antibiotic dressing may be applied to the wound.

Cryosurgery is often used to destroy precancerous skin lesions such as actinic keratoses but is rarely used alone (monotherapy) to treat skin cancer.

An area where skin tissue has been destroyed by freezing with liquid nitrogen usually heals in 3 to 6 weeks. After the procedure, keep the wound clean and dry. A scab will form over the area.

Cryosurgery is used more often for precancerous growths such as actinic keratoses than for skin cancer.

Cryosurgery is done to destroy skin cancer if:

• It is the first time a skin cancer has developed in that specific area (primary lesion).
• There are multiple skin cancers that need to be destroyed.
• You have a bleeding disorder.
• You cannot, or do not want to, use another procedure to remove a skin cancer.

When cryotherapy is used to treat actinic keratoses, the cure rate is nearly 99 out of 100.¹

If cryosurgery is used to treat skin cancer, there is a small chance that the skin cancer will return after treatment. One review of studies of basal cell skin cancer treated with cryosurgery found a cure rate of over 90 out of 100 people.²

The risks of cryosurgery include:

• Scarring, including a white spot (hypopigmentation).
• Pain or stinging during and after the procedure.
• A longer recovery time than other procedures that remove skin cancers.
• Infection.

Cryosurgery is an efficient procedure if there are many skin cancers that need to be destroyed or treated.

Cryosurgery wounds heal slowly and can be painful.

Cryosurgery destroys tissue, so there is no way to obtain a sample (biopsy) for diagnosis.

Complete the surgery information form (PDF) (What is a PDF document?) to help you prepare for this surgery.

Citations

1. Lubritz RR, Smolewski A (1982). Cryosurgery cure rate of actinic keratosis. Journal of the American Academy of Dermatology, 7: 631–632.
2. Kokoszka A, Scheinfeld N (2003). Evidence-based review of the use of cryosurgery in treatment of basal cell carcinoma. Dermatologic Surgery, (29)6: 566–570.

Author:	Bets Davis, MFA	Last Updated: October 14, 2008
Medical Review:	Kathleen Romito, MD - Family Medicine Alexander H. Murray, MD, FRCPC - Dermatology
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