Health Library Polyenes for Treating ThrushFrom Healthwise

Nystatin and amphotericin b are antifungal medicines that are placed directly on the white patches (topical treatment) caused by thrush.

Polyenes stop the growth of the yeast that causes thrush. This gives the body's immune system a better chance to destroy the yeast.

Polyenes are usually used to treat thrush in infants.

Doctors sometimes suggest nursing mothers treat their nipples with a polyene to prevent the infection spreading to their nipples.

Nystatin and amphotericin b are most effective when they come in direct contact with the affected area. For infants, treatment should be continued for at least 48 hours after the white patches have gone away.

Most babies and young children can be cured with this type of medicine.¹ Babies who have problems that weaken the body's immune system may need other medicines.

In persistent or recurrent infections, treatment may need to be continued beyond the normal treatment period.

The most common side effects are:

• Nausea.
• Vomiting.
• Diarrhea.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

Nystatin and amphotericin b work best when they come in contact with the yeast that causes thrush, so it is important to apply the medicine to both sides of the mouth. Swish the medicine around in your mouth for as long as possible before swallowing or spitting out.

Because nystatin preparation contains sugar, which can cause cavities, the person should rinse his or her mouth 5 to 10 minutes after taking the medicine.

Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.

Citations

1. Weinberg A, Levin MJ (2007). Candidiasis section of Infections: parasitic and mycotic. In WW Hay Jr et al., eds., Current Pediatric Diagnosis and Treatment, 18th ed., pp. 1240–1243. New York: McGraw-Hill.

Author:	Maria G. Essig, MS, ELS	Last Updated: March 10, 2008
Medical Review:	Michael J. Sexton, MD - Pediatrics Thomas Emmett Francoeur, MDCM, CSPQ, FRCPC - Pediatrics
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