
Aortic valve regurgitation is a problem with the aortic valve. This valve works like a one-way gate, opening so that blood from the left ventricle (the heart's main pump) can be pushed into the aorta, the large artery leaving the heart. From the aorta, blood flows into the other arteries and through the body. When the heart rests between beats, the aortic valve closes to keep blood from flowing backward into the heart. See a picture of how the aortic valve works.
But when you have aortic valve regurgitation, the aortic valve does not close as it should. With each heartbeat, some of the blood leaks back (regurgitates) through the aortic valve into the left ventricle. The body does not get enough blood, so the heart has to work harder to make up for it. See a picture of aortic valve regurgitation.
In most cases, it takes many years for symptoms to start. This is called chronic aortic valve regurgitation. The heart makes up for reduced blood flow by getting bigger so that it can pump out more blood. But if the valve problem is not fixed and the leaking gets worse, symptoms start. At this point, valve replacement surgery is often needed to prevent abnormal heartbeats, heart failure, and permanent damage to the heart.
In rare cases, the valve problem starts suddenly and without warning. This is called acute aortic valve regurgitation. It requires medical help right away.
In some people, only small amounts of blood leak back into the left ventricle. This normally does not cause any symptoms or problems. This topic focuses on the more severe cases where large amounts of blood leak back into the left ventricle.
Any condition that damages the aortic valve can cause aortic valve regurgitation. Common causes of chronic valve problems include:
The most common causes of sudden (acute) aortic valve regurgitation include:
Early on, people with chronic aortic valve regurgitation often do not have any symptoms. But as the heart pumps harder to make up for the valve problem, the heart gets weaker over time, and symptoms start. These symptoms include:
When the valve problem is acute, these symptoms are sudden, often more intense, and life-threatening.
Your doctor may suspect that you have this type of valve problem after hearing a heart murmur through a stethoscope. He or she will ask about your symptoms and past health and will want to know if you have any family history of heart disease.
You will get further tests, like an echocardiogram to confirm the diagnosis, to show how much the valve is leaking, and to see how well the left ventricle is working.
Your treatment will depend on what is causing your valve problem and if you have symptoms.
If your aortic valve regurgitation starts suddenly and is acute, you'll need valve replacement surgery right away.
But in most people, aortic valve regurgitation is chronic and starts slowly. So when people are first diagnosed, treatment is not needed. Your doctor will probably recommend some lifestyle changes to keep your heart healthy. He or she may advise you to:
Even when you aren't getting treatment, your doctor will see you regularly to check on your heart. In some cases, doctors prescribe medicine to lower blood pressure and delay the advance of the disease.
If symptoms appear or your heart does not pump as well, you will probably need valve replacement surgery.

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Learning about aortic valve regurgitation: | |
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Living with aortic valve regurgitation: |
Different factors cause sudden (acute) and long-standing (chronic) aortic valve regurgitation.
Causes of chronic aortic valve regurgitation include:
Acute regurgitation can be caused by:
Acute aortic valve regurgitation is an emergency that must be treated immediately with surgery.
More information |
Many young people who have aortic valve regurgitation do not have symptoms. When symptoms finally appear, they often indicate that the heart is significantly affected. Whether these symptoms come on gradually (as in chronic regurgitation) or more suddenly (as in acute regurgitation), they may be confused with symptoms of heart failure. See a picture of aortic valve regurgitation.
If only a small amount of blood is leaking back through the aortic valve, you may not have symptoms, and heart function may not be affected. As the amount of leakage increases, symptoms usually appear, and the function of the heart may be affected.
Acute aortic valve regurgitation is an emergency. Symptoms include:
If acute aortic valve regurgitation develops (for example, from an infection in the heart [endocarditis]), the only symptoms may be severe shortness of breath, a rapid heart rate, and lightheadedness.
The risk factors for aortic valve regurgitation are:
Tell your doctor if one of your close family members has a congenital aortic valve defect, because you may be at risk for having one.
As you age, your valves sustain greater wear and are more likely to leak, increasing the risk of aortic regurgitation. Also, men are more likely than women to develop the condition.
Age; a disorder of the connective tissues (Marfan's syndrome); high blood pressure; autoimmune diseases, in which your immune system begins to attack your body's own cells; and syphilis put you at increased risk for developing an enlarged aorta, which in turn increases your risk for regurgitation.
Call your doctor if you have symptoms of aortic valve regurgitation such as fainting, chest pain, or shortness of breath. For more information, see the Symptoms section of this topic. Your doctor will confirm whether you have valve problems or some other condition.
Acute aortic valve regurgitation comes on suddenly. Symptoms include severe shortness of breath, a rapid heart rate, lightheadedness, weakness, confusion, and chest pain.
Acute aortic valve regurgitation is a medical emergency. Call 911 immediately.
Health professionals who can diagnose aortic valve regurgitation include:
After you have been diagnosed, you may be referred to a cardiologist, who specializes in heart diseases. The specialist will monitor your condition and help determine when valve replacement is needed.
You should have a physical exam periodically, with the frequency depending on your age, overall health, and risk factors for various conditions. Most heart valve problems are discovered by a doctor while listening to the heart with a stethoscope. If your doctor finds aortic valve regurgitation during a routine physical, the condition will likely not have progressed to the point of being severe and needing immediate treatment. By treating the condition early, you may be able to extend, possibly even by several years, the time before you need valve replacement surgery. Because all artificial valves eventually wear out, this could mean one fewer valve replacement in your lifetime.
In testing for aortic valve regurgitation, your doctor will try to determine whether you have the condition and what type of regurgitation you have (acute or chronic). The doctor also will want to assess how severe the regurgitation is and whether you have any complications, such as abnormal heartbeats (arrhythmias) or heart failure.
A medical history and physical exam are a routine part of any evaluation of how well your heart is working. Aortic valve regurgitation can generally be diagnosed by physical exam.
Further testing may be needed to find out how much the valve is leaking. Tests also are needed if you have symptoms, because they can easily be confused with symptoms of several other heart conditions, including coronary artery disease (CAD) and heart failure. Aortic valve regurgitation also can be confused with other heart valve conditions.
During the physical exam, your doctor will listen for an extra heart sound (a murmur). If you have a certain type of heart murmur, your doctor may suspect aortic valve regurgitation and suggest further tests, which may include:
If you have aortic valve regurgitation, you will see your doctor for regular exams including an echocardiogram. How often you have an echocardiogram depends on the severity of your regurgitation. Mild regurgitation requires an echocardiogram every 2 to 3 years. A moderate condition requires an echo every year. And with severe regurgitation, you may have to have an echo every 4 to 6 months.
Treatment for aortic valve regurgitation usually depends on whether you have symptoms from your leaky heart valve and whether your heart is pumping effectively. Other factors that play a part in treatment decisions include your age (older people may be at greater-than-average risk for complications of some treatments), risks associated with surgery, and the experience of the doctor and health care facility performing the procedures.
If you have symptoms, surgical treatment may be needed. If your symptoms develop suddenly (acute aortic regurgitation), immediate surgery to replace the valve is usually needed.
The treatment for acute aortic regurgitation is usually limited to immediate surgery, so this treatment overview will discuss the treatment of chronic aortic valve regurgitation.
Your doctor will assess the cause and severity of your aortic valve regurgitation and how effectively your heart is able to compensate for it. In addition to some preliminary tests—including routine blood tests and an electrocardiogram—an exercise electrocardiogram (also called exercise EKG or cardiac stress test) can be done. This test will help you and your doctor see whether you have any symptoms while you are exercising.
An echocardiogram will probably be done too. The echocardiogram measures how much your valve is leaking, the size of your left ventricle, and your ejection fraction. These measurements help your doctor know when surgery is needed.
If your regurgitation is mild and you do not have any symptoms, your doctor may not prescribe daily heart medicines. If you have had rheumatic fever, you may need to take antibiotics daily for the following 5 to 10 years, depending on your heart's condition.
If your regurgitation is moderate to severe, your doctor may prescribe a high blood pressure medicine. These medicines include the calcium channel blocker nifedipine, an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), or the vasodilator hydralazine.
Since your heart is already working overtime to keep up with your body's needs, your doctor will probably recommend specific lifestyle changes to decrease your heart's workload.
Report any symptoms of chest pain, fainting, and shortness of breath to your doctor immediately. You will also need to follow up after 2 or 3 months for another screening and have regular appointments to find out whether your condition is getting worse.
Symptoms of chronic aortic valve regurgitation most commonly develop when you are in your 40s or 50s, but there is no way to gauge how quickly symptoms will develop in each case. Some people remain free of symptoms for decades, while in others, progression to symptoms takes 2 to 3 years.
Regardless, you will need to have regular echocardiograms (echos) to find out whether your aortic regurgitation is getting worse. The echocardiogram estimates your ejection fraction—the amount of blood that is leaving your left ventricle, the heart's main pump—and the size of your left ventricle. A declining ejection fraction and an increasing diameter of your left ventricle indicate decreasing heart function and worsening regurgitation.
Mild regurgitation requires an evaluation with an echocardiogram every 2 to 3 years. A moderate condition requires an echo every year. And with severe regurgitation, you may have to have an echo every 4 to 6 months.
The American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend having aortic valve replacement surgery if you have severe regurgitation and one of the following conditions:1
Your doctor may recommend that you have surgery even if you do not have symptoms, because symptoms typically only occur after the condition has progressed to the point that it has already damaged the heart.
It is extremely important that you report any symptoms or changes in your symptoms to your doctor. Your doctor will rely on you to provide an accurate assessment of how you feel and how your symptoms have changed since your last visit.
If you are not already taking medicines, at some point your doctor may prescribe a high blood pressure medicine. These medicines include the calcium channel blocker nifedipine, an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), or the vasodilator hydralazine.
If aortic valve regurgitation causes chest pain, medicines called nitrates (nitroglycerin) can sometimes be tried to help relieve the pain. Antiarrhythmic medicines may be needed if aortic valve regurgitation leads to abnormal heart rhythms (arrhythmias). If aortic valve regurgitation causes heart failure, medicines such as digoxin and diuretics are often used to help the heart pump more effectively.
People who have had rheumatic fever may need to take antibiotics daily for 5 to 10 years after the infection, depending on the damage to the heart.
Avoid getting sick from the flu. Get a flu shot every year.
Your doctor will stress that you quit smoking and avoid secondhand smoke, eat a heart-healthy diet, limit your sodium intake, and possibly follow an exercise program. If you can exercise, do activities that raise your heart rate. Prescribed exercise is often part of a cardiac rehabilitation program.
If your aortic valve regurgitation is getting worse and your heart is not able to compensate for the extra workload, your doctor will recommend that you have aortic valve replacement surgery, even if you do not have symptoms. But if you have symptoms, aortic valve replacement surgery is the only cure for aortic regurgitation.
The American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend having aortic valve replacement surgery if you have severe regurgitation and one of the following conditions:1
Your doctor may recommend that you have surgery even if you do not have symptoms, because symptoms typically only occur after the condition has progressed to the point that it has already damaged the heart.
Other risk factors, including age, speed of deterioration, and overall health, will also be considered in deciding the timing of surgery.
A small number of people may suffer from other severe and debilitating conditions that make valve replacement surgery too dangerous. Also, some people may choose not to have valve replacement surgery for personal or philosophical reasons. For example, a person may believe that he or she does not have enough remaining years to make surgery worthwhile.
People with symptomatic aortic valve regurgitation who do not have corrective surgery face progression to the severe stages of heart failure and, on average, have a life expectancy of 2 to 4 years. This means they will probably have to cope with an end stage to the disease. As you near the end stage of your condition, you may want to consider making advance directives, which are documents that allow you to determine the type of care you wish to receive in case you are not able to make your wishes known at the end of your life. For more information, see the topic Care at the End of Life.
More information |
After you are diagnosed with long-lasting (chronic) aortic valve regurgitation, be sure to work with your doctor to monitor the condition of your valve and report immediately any shortness of breath, fainting, chest pain, or other symptoms. (Symptoms of acute aortic valve regurgitation come on suddenly. Acute regurgitation is an emergency that requires immediate valve replacement surgery.)
Many people are surprised when diagnosed with chronic aortic valve regurgitation, because they do not have symptoms. People who have chronic regurgitation, even when it's moderate or severe, can have a good prognosis for many years.
Even though you may feel fine, it is important to guard against a false sense of security during this stage of chronic aortic valve regurgitation. Significant damage can occur to your heart during this period.
If you have symptoms, valve replacement surgery is the only cure for aortic valve regurgitation. If you cannot or choose not to have surgery, you likely will develop heart failure and your life span will be greatly reduced. The condition usually reduces average life expectancy to about 2 years if you develop heart failure and 4 years if you develop chest pain (angina).2 With corrective surgery, you may reach a normal life expectancy. For more information, see the topic Heart Failure.
Symptoms of chronic regurgitation most commonly develop in a person's 40s or 50s. But there is no way to gauge how quickly symptoms will develop in any one person. Some people can remain symptom-free for decades. In others, progression to symptoms takes 2 to 3 years. You may develop symptoms more quickly if the left ventricle does not contract fully (depressed systolic function).
Complications may develop from severe, symptomatic chronic aortic valve regurgitation. Heart failure, an infection in your heart (endocarditis), and irregular heartbeats (arrhythmias) are all common complications of aortic valve regurgitation that can be delayed if not prevented entirely. Reducing your risk factors for these conditions can help prevent complications. For instance, because both high blood pressure (hypertension) and regurgitation can cause heart failure, if you have both it is especially important to control your blood pressure.
It may be better to have valve replacement surgery before symptoms develop from regurgitation. If the left ventricle becomes significantly enlarged, heart damage can be irreversible. The left ventricle can enlarge even while you are symptom-free. For this reason, visit your doctor regularly for appropriate monitoring.
More information |
Having aortic valve regurgitation means your heart is working overtime to keep up with your body's needs. So your doctor will probably recommend specific lifestyle changes to decrease your heart's workload.
If you have an artificial valve, you may need to take antibiotics before you have certain dental or surgical procedures. The antibiotics help prevent an infection in your heart called endocarditis.
People who have had rheumatic fever may need to take antibiotics for 5 to 10 years following the infection, depending on the damage to the heart.
If you have severe aortic valve regurgitation, your doctor will probably recommend that you avoid strenuous physical activity.
If you have chronic aortic regurgitation, you are likely to live for many years without symptoms. During this symptom-free period, you need to monitor the function of the lower left chamber of the heart (left ventricle) with regular doctor visits and echocardiogram tests. How often you need to see your doctor depends on the severity of your condition. Follow-up visits are generally scheduled every 6 to 12 months.
Report any symptoms of chest pain, fainting, and shortness of breath to your doctor immediately. These are signs that you are likely to need surgery.
More information |
Treatment for chronic aortic valve regurgitation includes medicines to reduce blood pressure. If you have valve replacement surgery, you will need to take medicines to prevent infection and blood clots around the artificial valve.
If your regurgitation is moderate to severe, your doctor may prescribe a high blood pressure medicine. These medicines include the calcium channel blocker nifedipine, an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), or the vasodilator hydralazine.
If aortic valve regurgitation causes chest pain, medicines called nitrates (nitroglycerin) can sometimes be tried to help relieve the pain. Antiarrhythmic medicines may be needed if the regurgitation leads to irregular heart rhythms (arrhythmias). If aortic valve regurgitation causes heart failure, medicines are often used to help the heart pump more effectively. These include digoxin and diuretics.
If your valve is replaced with an artificial heart valve made of plastic, metal, or cloth, you will have to take anticoagulant medicine, such as warfarin (Coumadin), for the rest of your life to prevent blood clots.
When you take warfarin, you need to take extra steps to avoid bleeding problems. You need to:
For more information, see:
If you have an artificial valve, you may need to take antibiotics before you have certain dental or surgical procedures. The antibiotics help prevent an infection in your heart called endocarditis.
People who have had rheumatic fever may need to take antibiotics for 5 to 10 years after the infection, depending on the damage to the heart.
Valve replacement surgery is the only cure for sudden (acute) aortic valve regurgitation or for long-term (chronic) regurgitation when symptoms develop or signs show that the lower left heart chamber (left ventricle) is starting to fail.
The American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend having aortic valve replacement surgery if you have severe regurgitation and one of the following conditions:1
Your doctor may recommend that you have surgery even if you do not have symptoms, because symptoms typically only occur after the condition has progressed to the point that it has already damaged the heart.
If you choose to have aortic valve replacement surgery, you can expect to live to a normal or near-normal life expectancy. There are some risks associated with surgery. But the risk of dying during surgery overall is still reasonably low (5% or less).1 You may be at higher risk for complications if your left ventricle is working poorly. Surgery may not be recommended in some people who are in extremely poor health.
If you have valve replacement surgery, a mechanical or tissue valve will be used to replace your heart valve. Before you have surgery, you and your doctor will decide on which type of valve is right for you. To help with this decision, see:
More information |
| Society of Thoracic Surgeons | |
| 633 North Saint Claire Street | |
| Suite 2320 | |
| Chicago, IL 60611 | |
| Phone: | (312) 202-5800 |
| Fax: | (312) 202-5801 |
| Email: | sts@sts.org |
| Web Address: | www.sts.org |
The Society of Thoracic Surgeons provides patient information on surgeries of the chest and throat that are done by cardiothoracic surgeons. These surgeries include heart, lung, and throat surgery. The patient information section of the Web site describes diseases, surgeries, patient options, and what to expect after surgery. And using the Web site, you can search for surgeons in your area. | |
| American Heart Association (AHA) | |
| 7272 Greenville Avenue | |
| Dallas, TX 75231 | |
| Phone: | 1-800-AHA-USA1 (1-800-242-8721) |
| Web Address: | www.heart.org |
Visit the American Heart Association (AHA) website for information on physical activity, diet, and various heart-related conditions. You can search for information on heart disease and stroke, share information with friends and family, and use tools to help you make heart-healthy goals and plans. Contact the AHA to find your nearest local or state AHA group. The AHA provides brochures and information about support groups and community programs, including Mended Hearts, a nationwide organization whose members visit people with heart problems and provide information and support. | |
| National Heart, Lung, and Blood Institute (NHLBI) | |
| P.O. Box 30105 | |
| Bethesda, MD 20824-0105 | |
| Phone: | (301) 592-8573 |
| Fax: | (240) 629-3246 |
| TDD: | (240) 629-3255 |
| Email: | nhlbiinfo@nhlbi.nih.gov |
| Web Address: | www.nhlbi.nih.gov |
The U.S. National Heart, Lung, and Blood Institute (NHLBI) information center offers information and publications about preventing and treating:
| |
| Texas Heart Institute | |
| P.O. Box 20345 | |
| Houston, TX 77225-0345 | |
| Phone: | 1-800-292-2221 (Heart Information Service hotline) (832) 355-4011 (general line) |
| Email: | his@heart.thi.tmc.edu (Heart Information Services) |
| Web Address: | www.texasheartinstitute.org |
The Texas Heart Institute's national telephone hotline is staffed by medical professionals who can answer heart-related health questions. The Web site provides information on a wide range of heart topics, including common disorders and prevention programs. | |
Citations
- Bonow RO, et al. (2006) ACC/AHA 2006 guidelines for the management of patients with valvular heart disease. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease). Circulation, 114(5): e84–e231.
- Otto CM, Bonow RO (2008). Aortic regurgitation section of Valvular heart disease. In P Libby et al., eds., Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 8th ed., pp. 1635–1646. Philadelphia: Saunders Elsevier.
Other Works Consulted
- Bonow RO, et al. (2008). 2008 Focused update incorporated into the ACC/AHA 2006 Guidelines for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing committee to revise the 1998 Guidelines for the management of patients with valvular heart disease). Circulation, 118(15): e523–e661.
- Curtin RJ, Griffin BP (2006). Valvular heart disease. In DC Dale, DD Federman, eds., ACP Medicine, section 1, chap. 11. New York: WebMD.
- Hirsch J, et al. (2008). Executive summary: American College of Chest Physicians evidence-based clinical practice guidelines (8th ed.). Chest, 133(6): 71S–109S.
- Nishimura RA, et al. (2008). ACC/AHA 2008 guideline update on valvular heart disease: Focused update on infective endocarditis: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: Endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation, 118(8): 887–896.
- Oakley RE, et al. (2008). Choice of prosthetic heart valve in today's practice. Circulation, 117(2): 253–256.
- Rosengart TK, et al. (2008). Percutaneous and minimally invasive valve procedures: A scientific statement from the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplinary Working Group, and Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation, 117(13): 1750–1767.
- Smith SC, et al. (2006). AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: Endorsed by the National Heart, Lung, and Blood Institute. Circulation, 113(19): 2363–2372. [Erratum in Circulation, 113(22): 847.]
- Stewart WJ, Carabello BA (2007). Aortic valve disease. In EJ Topol et al., eds., Textbook of Cardiovascular Medicine, 3rd ed., pp. 366–388. Philadelphia: Lippincott Williams and Wilkins.
- Stout KK, Verrier ED (2009). Acute valvular regurgitation. Circulation, 119(25): 3232–3241.
| By | Healthwise Staff |
|---|---|
| Primary Medical Reviewer | E. Gregory Thompson, MD - Internal Medicine |
| Specialist Medical Reviewer | George Philippides, MD - Cardiology |
| Last Revised | January 7, 2010 |
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Author: Healthwise Staff
Medical Review: E. Gregory Thompson, MD - Internal Medicine & George Philippides, MD - Cardiology
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