Health Library Aspirin for Peripheral Arterial DiseaseFrom Healthwise

Brand-name aspirin is no more effective than generic or store brands.

Aspirin helps prevent the formation of blood clots. This can decrease the chance that a blood clot will form and block an already-narrowed artery.

Aspirin may be given to people who have peripheral arterial disease (PAD) or risk factors for peripheral arterial disease. It may also be used after bypass surgery or angioplasty to prevent the formation of blood clots after these procedures.

Research results vary on the effects of aspirin for PAD, but it likely reduces the risk for heart attack and stroke.¹

Side effects of aspirin include:

• Inflammation of the stomach (gastritis).
• Gastrointestinal bleeding.
• An allergic reaction.
• In rare cases, bruising and bleeding (hemorrhage) in the brain or other internal organs of the body.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

Aspirin may be combined with other antiplatelet or anticoagulant medicines.

Some doctors are concerned that long-term daily aspirin use can increase the risk of stomach problems. A smaller dose, such as a single low-dose aspirin, is often used and appears to be just as effective as a higher dose. Consult your doctor before you start taking aspirin on a regular basis.

Because of aspirin's effect on blood clotting, your doctor may want you to stop your aspirin at least 5 to 10 days before surgery and before any dental procedure that may cause excessive bleeding.

Aspirin may also lower the risk of heart attack and stroke, which are common causes of death in people who have PAD.

Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.

Citations

1. Regensteiner JG, Hiatt WR (2002). Current medical therapies for patients with peripheral arterial disease: A critical review. American Journal of Medicine, 112(1): 49–57.

Author:	Robin Parks, MS	Last Updated: October 30, 2007
Medical Review:	Anne C. Poinier, MD - Internal Medicine David A. Szalay, MD - Vascular Surgery
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