Examples
|
| hydroxyurea | Droxia, Hydrea |
Hydroxyurea is taken daily by mouth (orally).
How It Works
Hydroxyurea increases
fetal hemoglobin (HbF) production and slightly raises
the total
hemoglobin concentration in the body. Fetal hemoglobin
reduces the chance that red blood cells will sickle in a person who has
sickle cell disease. So increased production of HbF
can reduce the occurrence of sickling-related complications.
Why It Is Used
Hydroxyurea is used to reduce
complications of sickle cell disease in adults who have a history of severe
symptoms, including:
How Well It Works
Hydroxyurea can reduce the number
of painful events and the recurrence of acute chest syndrome. It also can
reduce hospital stays and the need for
blood transfusion in adults who have sickle cell
disease.1 This medicine doesn't work for everyone though.
Hydroxyurea is still an experimental treatment for young children with
sickle cell disease. So far, research shows that hydroxyurea is as effective
for children as for adults. More research is needed about long-term side
effects.2
Side Effects
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
- Usually the benefits of the medicine are more important than any minor side effects.
- Side effects may go away after you take the medicine for a while.
- If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.
Call 911 or other emergency services right away if you have:
- Trouble breathing.
- Hives.
- Swelling of your face, lips, tongue, or throat.
Call your doctor right away if you have:
- Fever, chills, or a cough.
- Lower back or side pain.
- Pain or difficulty when you urinate.
Common side effects of this medicine include:
- Diarrhea.
- Nausea or vomiting.
- Drowsiness.
See Drug Reference
for a full list of side effects. (Drug Reference is not available in all
systems.)
What To Think About
While taking hydroxyurea, you will have regular frequent blood tests to check your bone marrow, liver, and kidneys.
Taking medicine
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Pregnancy advice for women and men
If you need to take this medicine, talk to your doctor about how you can prevent pregnancy.
For women: Do not use this medicine if you are pregnant or planning to get pregnant.
For men: Do not use this medicine if you and your partner are planning to get pregnant.
Checkups
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
References
Citations
- Meremikwu MM (2009). Sickle cell disease, search date
September 2007. Online version of BMJ Clinical Evidence:
http://www.clinicalevidence.com.
- Strouse JJ, et al. (2008). Hydroxyurea for sickle cell disease: A systematic review for efficacy and toxicity in children. Pediatrics, 122(6): 1332–1342.
Credits
| By | Healthwise Staff |
|---|
| Primary Medical Reviewer | E. Gregory Thompson, MD - Internal Medicine |
|---|
| Specialist Medical Reviewer | Martin Steinberg, MD - Hematology |
|---|
| Last Revised | October 7, 2010 |
|---|
Meremikwu MM (2009). Sickle cell disease, search date
September 2007. Online version of BMJ Clinical Evidence:
http://www.clinicalevidence.com.
Strouse JJ, et al. (2008). Hydroxyurea for sickle cell disease: A systematic review for efficacy and toxicity in children. Pediatrics, 122(6): 1332–1342.
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