
A peptic ulcer is a sore in the inner lining of the stomach or upper small intestine (duodenum). Ulcers develop when the intestine or stomach's protective layer is broken down. When this happens, digestive juices can damage the intestine or stomach tissue. These strong juices, which contain hydrochloric acid and an enzyme called pepsin, also can injure the esophagus. The esophagus is the tube that leads from your throat to your stomach.
Peptic ulcers are no longer a condition that most people have to live with their entire lives. Treatment cures most ulcers. And symptoms go away quickly.
Peptic ulcers that form in the stomach are called gastric ulcers. Those that form in the upper small intestine are called duodenal (say "doo-uh-DEE-nul" or "doo-AW-duh-nul") ulcers.
See a picture of the stomach and duodenum.
The two most common causes of peptic ulcers are:
H. pylori and NSAIDs break down the stomach or intestine’s protective mucus layer. The mucus layer prevents digestive juices from damaging the stomach and intestine.
Symptoms include:
Different people have different symptoms, and some people have no symptoms at all.
Your doctor will ask you questions about your symptoms and your general health, and he or she will do a physical exam.
If your symptoms are not severe and you are younger than 55, your doctor may do some simple tests (using your blood, breath, or stool) to look for signs of H. pylori infection.
The only way for you and your doctor to know for sure if you have an ulcer is to do a more complicated test, called an endoscopy, to look for an ulcer and to test for H. pylori infection. An endoscopy allows the doctor to look inside your esophagus, stomach, and small intestine. An endoscopy is usually done by a gastroenterologist, a doctor who specializes in digestive diseases.
To treat peptic ulcers, most people need to take medicines that reduce the amount of acid in the stomach. If you have an H. pylori infection, you will also need to take antibiotics. If your doctor prescribes antibiotics to treat your infection, take them as directed. Do not stop taking them just because you feel better. You need to take the full course of antibiotics. It is much more likely that the infection will be cured if you take all the antibiotics.
You can help speed the healing of your ulcer and prevent it from coming back if you quit smoking and limit alcohol. Continued use of medicines such as aspirin, ibuprofen, or naproxen may increase the chance of your ulcer coming back.
Ignoring symptoms of an ulcer is not a good idea. This condition needs to be treated. While symptoms can go away for a short time, you may still have an ulcer. Left untreated, an ulcer can cause life-threatening problems. Even with treatment, some ulcers may come back and may need more treatment.
Frequently Asked Questions
Learning about peptic ulcer disease: | |
Being diagnosed: | |
Getting treatment: | |
Ongoing concerns: |
The two most common causes of peptic ulcer disease are infection with Helicobacter pylori (H. pylori) bacteria and use of nonsteroidal anti-inflammatory drugs (NSAIDs).
Although many people are infected with H. pylori bacteria, only a few of them will develop peptic ulcer disease. Certain factors make a person with an H. pylori infection more likely to get an ulcer. Some of these factors, not all of which are well understood, include:
Most peptic ulcers that are not caused by an H. pylori infection are caused by the use of NSAIDs. NSAIDs may be prescribed to control pain or inflammation caused by long-term (chronic) diseases such as arthritis or headaches. When used for weeks or months, NSAIDs can damage the lining of the digestive tract, causing an ulcer or making an existing ulcer worse.
A rare cause of peptic ulcers is Zollinger-Ellison syndrome. In this condition, the stomach greatly overproduces acid, damaging the stomach lining.
Although there is no evidence to prove that emotional or mental stress causes ulcers, it does seem to make ulcers worse in some people. But the connection is still controversial. And there are no specific recommendations for using counseling or psychotherapy to treat peptic ulcers.
The symptoms of a peptic ulcer vary and, by themselves, are not a reliable way to tell whether you have an ulcer. Also, some people may not have symptoms.
The symptoms of an ulcer often can be confused with other abdominal conditions, such as dyspepsia or gastroesophageal reflux disease (GERD).
Common ulcer symptoms include:
Less common but more serious symptoms of ulcers include:
Symptoms of ulcers in the upper small intestine (duodenal ulcers) and in the stomach (gastric ulcers) are similar, except for when pain occurs.
Some ulcers do not cause symptoms. These are known as silent ulcers. Silent ulcers are more common in older adults, people who have diabetes, or people who use nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen (Advil), or naproxen (Aleve).
Complications of an ulcer include bleeding, perforation, penetration, or obstruction of the digestive tract. Complications can happen in both silent ulcers and ulcers that cause symptoms.
In children, symptoms vary with age:
Many people who have peptic ulcers may not seek medical attention when their symptoms begin. Their symptoms, such as belly pain, may come and go for some time and may alternate with pain-free periods. Even without treatment, some ulcers will heal by themselves.
And even with treatment, some ulcers may come back. Certain factors such as cigarette smoking and continued use of nonsteroidal anti-inflammatory drugs (NSAIDs) increase the risk of ulcer recurrence.
Sometimes ulcers can cause complications, such as bleeding, perforation, penetration, or obstruction.
Most peptic ulcers without complications heal, regardless of the cause. But an ulcer is likely to come back if you have an H. pylori infection that is not successfully treated. Recurring ulcers caused by reinfection with H. pylori are not common in the United States, except in areas that are overcrowded or have poor sanitation.
If you have a history of ulcers, taking NSAIDs regularly raises your chances of getting another ulcer. If you stop using these medicines, you can reduce your chances of getting another ulcer.
The following factors can increase your chance of developing a peptic ulcer and may slow the healing of an ulcer if you already have one. You may be able to reduce the risk of developing an ulcer by controlling or eliminating these factors, which include:
Some factors that you cannot control may increase your risk of developing an ulcer. These include:
In the past, eating spicy foods or drinking caffeine or moderate amounts of alcohol were thought to increase your risk of getting an ulcer. This is no longer believed to be true. But although certain foods or certain beverages may not increase your risk of developing an ulcer, they may cause symptoms of heartburn or indigestion. You may need to avoid them if they bother you.
Although there is no evidence to prove that emotional or mental stress causes ulcers, it does seem to make ulcers worse in some people. But the connection is still controversial. And there are no specific recommendations for using counseling or psychotherapy to treat peptic ulcers.
If you have been diagnosed with a peptic ulcer, call 911 or other emergency services immediately if you have:
Call your doctor if you have been diagnosed with a peptic ulcer and:
If you have been diagnosed with a peptic ulcer and medical treatment is not helping, call your doctor. Waiting until your symptoms get worse can be serious.
If you do not know if you have a peptic ulcer and you do not have any of the emergency symptoms listed above, you may try taking an antacid or nonprescription acid reducer and other home treatment, such as making changes to your diet.
To evaluate your symptoms, see your:
If further testing or specialized treatment is needed, you may need to see someone who specializes in the treatment of diseases of the digestive tract (gastroenterologist).
If surgery is needed, your doctor may refer you to a general surgeon. But surgery is rarely needed to treat ulcers.
To prepare for your appointment, see the topic Making the Most of Your Appointment.
The tests needed to diagnose peptic ulcer disease may depend on your symptoms and on a medical history and physical exam.
If you are a younger adult who is having ulcer symptoms for the first time, your doctor may begin treatment with medicines based only on your symptoms and the results of your medical history and physical exam. But it is becoming more common to test your blood, breath, or stool immediately for Helicobacter pylori (H. pylori) infection whenever someone has common ulcer symptoms.
If you are older than 55, you may require more testing because you may be at increased risk for stomach cancer. Although the risk of stomach cancer is small, it is important to distinguish between a gastric and duodenal ulcer. If you have a stomach ulcer, it will be tested for cancer. In rare cases, stomach ulcers contain cancer cells. Further testing is needed, especially for those people older than 55 who have:
When a person has symptoms of a peptic ulcer, the following tests may be used to look for the ulcer:
A fecal occult blood test (FOBT) may be done to detect blood in the stool, which may be caused by a peptic ulcer or another serious problem, such as colon cancer. By itself, an FOBT cannot diagnose peptic ulcer disease, but it may show if an ulcer is bleeding.
A complete blood count (CBC) also may be done to look for anemia, which may be caused by a bleeding ulcer.
Many people are infected with H. pylori bacteria, but most of them will not have symptoms of peptic ulcer disease. Because of this, the American College of Gastroenterology advises testing for H. pylori infection for people who:1
Some doctors prefer to test for H. pylori infection in everyone who has common ulcer symptoms.
Your doctor may advise a screening for H. pylori before long-term NSAID use is begun. Screening and treatment for H. pylori infection has been shown to reduce the risk of ulcers for people starting long-term NSAID use.2 Anyone taking NSAIDs should discuss with his or her doctor the potential risks of long-term NSAID use.
Helicobacter pylori tests cannot diagnose peptic ulcer disease or other conditions that may cause symptoms similar to an ulcer. These tests can only determine whether H. pylori bacteria are present. The most common tests used to detect an infection with H. pylori bacteria include:
Some people who have received therapy with medicines to treat an H. pylori infection need follow-up testing to make sure that the infection is cured.
Treatment for peptic ulcer disease includes one or more of the following:
Initial treatment of peptic ulcer disease depends on its cause.
No matter what is causing your ulcer, it is important to stop taking NSAIDs and to quit smoking.
If you feel that you need to continue to use nonsteroidal anti-inflammatory drugs (NSAIDs) after being diagnosed with a peptic ulcer, work with your doctor to find an alternative pain reliever. Use of NSAIDs can slow the healing of an ulcer or even prevent it from healing. If you must continue to use NSAIDs, your doctor may recommend that you take an NSAID that is less likely to cause ulcers. Or your doctor may prescribe a medicine that you take daily to help prevent ulcers. Medicines that help prevent ulcers include:
If ulcer symptoms do not respond to treatment, follow up with your doctor to be sure Helicobacter pylori (H. pylori) bacteria have been identified and treated. Most peptic ulcers are caused by infection with H. pylori bacteria. Persistent infection will likely be treated with an alternate combination of medicines. Antibiotic treatment for H. pylori should be taken exactly according to your doctor's instructions for it to be effective.
Tests such as the urea breath test and a stool antigen test can determine whether an H. pylori infection has been cured. If you have a history of ulcer complications or a family history of stomach cancer, you may need an endoscopy so that your doctor can look at the inside of your stomach and upper small intestine to see whether an ulcer is present. An endoscopy can also be used to collect a tissue sample (biopsy) that can be tested for H. pylori or cancer. For more information on these tests, see the Exams and Tests section of this topic.
Recurring ulcers caused by an infection with Helicobacter pylori (H. pylori) bacteria will likely be treated with a different combination of medicines.
Your doctor may conduct follow-up tests to find out whether an infection with H. pylori has continued or returned. Tests for H. pylori may include a test of your breath or stool and a biopsy of your stomach lining. For more information on these tests, see the Exams and Tests section of this topic.
If you have experienced significant complications from a peptic ulcer such as bleeding or obstruction, you may need an endoscopy, even if you have already had one. If your stomach or intestine has a perforation or your ulcer continues to bleed despite treatment, you may require surgery. But surgery is rarely used to treat an ulcer.
You can greatly reduce the chance that you will get a peptic ulcer if you:
If you are being treated for a peptic ulcer, your doctor will likely prescribe medicines and encourage you to try some home treatment methods. To stop symptoms and help an ulcer heal, you can:
Many people who have mild symptoms that could be caused by a peptic ulcer first try home treatment for a short time without seeing a doctor. But if you have ulcer symptoms that do not improve after 10 to 14 days of home treatment, or if you have other symptoms such as weight loss, nausea after eating, or consistent pain, it is be sure to see your doctor to make certain you have an ulcer and not some other more serious illness. This is even more important if you are middle-aged or older, because the risk for cancer or other illnesses that cause symptoms similar to peptic ulcer disease increases with age.
Medicines are usually a very effective treatment for ulcers. The bland diets that in the past were part of ulcer treatment are no longer required. This means people with peptic ulcers do not have to drink lots of milk or avoid spicy foods.
Most peptic ulcers can be cured and prevented from coming back by eliminating Helicobacter pylori (H. pylori) infections and avoiding nonsteroidal anti-inflammatory drugs (NSAIDs).
Medicines are used to:
Medicines that reduce the amount of acid produced by the stomach are used to treat all forms of peptic ulcer disease.
Proton pump inhibitors may be taken with antibiotics if the ulcer is caused by an H. pylori infection.
Doctors prescribe combination drug therapy to cure infection with H. pylori bacteria. Combination drug therapy usually includes at least two antibiotics, a proton pump inhibitor, and sometimes a bismuth compound.
Medicines used to protect the stomach from damage caused by frequent use of aspirin or other NSAIDs include:
Ulcers in the stomach (gastric ulcers) often heal more slowly than ulcers in the upper small intestine (duodenal ulcers).
You can get some H2 blockers and PPIs without a prescription (over-the-counter or OTC). If you are using OTC acid reducers (such as Prilosec or Pepcid) to help with your symptoms for more than 10 to 14 days at a time, or if your symptoms are very bad, be sure to see your doctor.
Surgery is rarely needed to treat peptic ulcers. Very effective medicine treatments are available to help heal ulcers. Treatment of a Helicobacter pylori (H. pylori) infection prevents most ulcers from coming back.
Surgery is needed sometimes to treat:
When surgery is done to treat an ulcer, it usually involves one or more of the following:
Because medicine for peptic ulcers works so well, surgery is rarely needed. If surgery is suggested, you may want to:
There is no other treatment available for uncomplicated peptic ulcers at this time.
| American College of Gastroenterology | |
| P.O. Box 342260 | |
| Bethesda, MD 20827-2260 | |
| Phone: | (301) 263-9000 |
| Web Address: | www.acg.gi.org |
The American College of Gastroenterology is an organization of digestive disease specialists. The Web site contains information about common gastrointestinal problems. | |
| American Gastroenterological Association | |
| 4930 Del Ray Avenue | |
| Bethesda, MD 20814 | |
| Phone: | (301) 654-2055 |
| Fax: | (301) 654-5920 |
| Web Address: | www.gastro.org |
The American Gastroenterological Association is a society of doctors who specialize in the digestive system (gastroenterologists). This Web site can help you find a gastroenterologist in your area. They also have patient information on many gastrointestinal diseases and disorders. | |
| National Digestive Diseases Information Clearinghouse | |
| 2 Information Way | |
| Bethesda, MD 20892-3570 | |
| Phone: | 1-800-891-5389 |
| Fax: | (703) 738-4929 |
| TDD: | 1-866-569-1162 toll-free |
| Email: | nddic@info.niddk.nih.gov |
| Web Address: | www.digestive.niddk.nih.gov |
This clearinghouse is a service of the U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the U.S. National Institutes of Health. The clearinghouse answers questions; develops, reviews, and sends out publications; and coordinates information resources about digestive diseases. Publications produced by the clearinghouse are reviewed carefully for scientific accuracy, content, and readability. | |
Citations
- Chey WD, et al. (2007). American College of Gastroenterology guideline of the management of Helicobacter pylori infection. American Journal of Gastroenterology, 102(8): 1808–1825.
- Lanza FL, et al. (2009). Guidelines for prevention of NSAID-related ulcer complications. American Journal of Gastroenterology, 104(3): 728–738.
| By | Healthwise Staff |
|---|---|
| Primary Medical Reviewer | Kathleen Romito, MD - Family Medicine |
| Specialist Medical Reviewer | Jerome B. Simon, MD, FRCPC, FACP - Gastroenterology |
| Last Revised | February 24, 2010 |
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ReferencesLast Revised: February 24, 2010
Author: Healthwise Staff
Medical Review: Kathleen Romito, MD - Family Medicine & Jerome B. Simon, MD, FRCPC, FACP - Gastroenterology
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