Health Library Beta-Sitosterol Plant ExtractFrom Healthwise

What is beta-sitosterol plant extract?

Beta-sitosterol is one of many sterols (phytosterols) that come from plants and have a structure like the cholesterol produced in the body. You can find phytosterols in most plants and thus in foods such as rice bran, wheat germ, corn oils, soybeans, and peanuts. Beta-sitosterol is also available as a dietary supplement.

What is beta-sitosterol used for?

Beta-sitosterol is said to lower cholesterol levels and reduce the risk of colon cancer. It also is said to relieve symptoms of benign prostatic hyperplasia (BPH), such as waking up many times at night to urinate. How beta-sitosterol works is not known. It may be related to cholesterol metabolism or anti-inflammatory effects.

There is limited evidence that beta-sitosterol does relieve the symptoms of BPH.¹ Research supports the fact that phytosterols, including beta-sitosterol, can reduce cholesterol levels. One study found no evidence that phytosterols reduce the risk of cancer.²

Is beta-sitosterol safe?

Few problems have been reported among men taking beta-sitosterol for BPH. Some men may have problems with their stomach and digestion. Beta-sitosterol's ability to prevent complications of BPH is not known.

Men who have problems urinating should see a doctor to rule out prostate cancer or other diseases. Prostate cancer is treatable, but treatment may be more successful when you find and treat the cancer as early as possible.

The U.S. Food and Drug Administration (FDA) does not regulate dietary supplements in the same way it regulates medicine. A dietary supplement can be sold with limited or no research on how well it works.

Always tell your doctor if you are using a dietary supplement or if you are thinking about combining a dietary supplement with your conventional medical treatment. It may not be safe to forgo your conventional medical treatment and rely only on a dietary supplement. This is especially important for women who are pregnant or breast-feeding.

When using dietary supplements, keep in mind the following:

• Like conventional medicines, dietary supplements may cause side effects, trigger allergic reactions, or interact with prescription and nonprescription medications or other supplements you might be taking. A side effect or interaction with another medication or supplement may make other health conditions worse.
• The way dietary supplements are manufactured may not be standardized. Because of this, how well they work or any side effects they cause may differ among brands or even within different lots of the same brand. The form of the supplement that you buy in health food or grocery stores may not be the same as the form used in research.
• Other than for vitamins and minerals, the long-term effects of most dietary supplements are not known.

• Benign Prostatic Hyperplasia (BPH)
• Complementary Medicine

Citations

1. Webber R (2006). Benign prostatic hyperplasia, search date May 2005. Online version of Clinical Evidence (15): 1–14.

2. Normén AL, et al. (2001). Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. American Journal of Clinical Nutrition, 74(1): 141–148.

Other Works Consulted

• Beta sitosterol (2004). In A DerMarderosian, J Beutler, eds., Review of Natural Products. St. Louis: Wolters Kluwer Health.

Author:	Caroline Rea, RN, BS, MS	Last Updated: June 27, 2007
Medical Review:	Kathleen Romito, MD - Family Medicine Marc S. Micozzi, MD, PhD - Policy Institute for Integrative Medicine
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