Health Library Should I Take Statins for High Cholesterol?From Healthwise

This information will help you understand your choices, whether you share in the decision-making process or rely on your doctor's recommendation.

Key points in making your decision

Lowering your high cholesterol can help you prevent a heart attack or stroke. Consider the following when making your decision:

• High cholesterol is only one of several risk factors for heart disease. To reduce your risk of coronary artery disease (CAD) and heart attack, you need to reduce all of your risk factors, not just high cholesterol.
• Guidelines from the U.S. National Cholesterol Education Panel recommend more intensive treatment with statins for people who are at moderate to very high risk of CAD.¹ It is important, however, that you discuss with your doctor whether statins are appropriate for you individually, based on your condition and medical history.
• The choice is less clear for people who have moderately high cholesterol and few risk factors for CAD and heart attack. This group may find this decision point most helpful.
• Therapeutic lifestyle changes are as important as medicine in reducing your risk for CAD and heart attack. For some people, quitting smoking, reducing blood pressure, losing weight, or getting more exercise can have the same or greater impact on reducing the risk of heart disease than taking medicine.

What is cholesterol, and why is high cholesterol dangerous?

Cholesterol is a type of fat. Your body needs it for many things, such as making new cells. But too much cholesterol in your blood increases your chances of heart attack and stroke.

What raises my chances of getting CAD and having a heart attack or stroke?

Your chances are higher if you:

• Are a man age 45 or older or a woman age 55 or older.
• Have a family history of CAD: CAD in your father or a brother younger than 55 or in your mother or a sister younger than 65.
• Have smoked any cigarettes within the past 30 days.
• Have high blood pressure (140/90 mm Hg or above) or are taking medicine for high blood pressure.
• Have a low HDL cholesterol level (below 40 mg/dL or 0.91 mmol/L).
• Have diabetes.

What are other risk factors?

Other factors that put you at risk for CAD and heart attack include high homocysteine levels, obesity and lack of regular exercise, menopause and the drop in estrogen that follows it, and metabolic syndrome.

An important part of your decision about whether to take statins is determining your risk for coronary artery disease and heart attack.

Use this Interactive Tool: Are You at Risk for a Heart Attack?

Along with medical guidelines for taking medicines, your decision about whether to take statins to lower your cholesterol level includes your personal feelings.

Medicine choices

Statins and statin combinations are the most effective and widely prescribed cholesterol-lowering medicine. They include:

• Atorvastatin (Lipitor).
• Atorvastatin with amlodipine (Caduet).
• Ezetimibe with simvastatin (Vytorin).
• Fluvastatin (Lescol).
• Lovastatin (Mevacor).
• Pravastatin (Pravachol).
• Rosuvastatin (Crestor).
• Simvastatin (Zocor).

Other medicines also lower cholesterol, and some may be used to lower triglycerides or raise HDL. They include:

• Bile acid sequestrants: cholestyramine (Questran) and colestipol (Colestid).
• Fibric acid derivatives: gemfibrozil (Lopid) or fenofibrate (Tricor).
• Nicotinic acid: (Nicolar, Niacor, Niaspan, and Slo-Niacin).

These medicines are sometimes used in combination with a statin.

These personal stories may be helpful in making your decision.

Use this worksheet to help you make your decision. After completing it, you will have a better idea of how you feel about taking medicine to lower cholesterol levels. Discuss the worksheet with your doctor.

Circle the answer that best applies to you.

*NA = Not applicable

Use the following space to list any other important concerns you have about this decision.

What is your overall impression?

Your answers in the above worksheet are meant to give you a general idea of where you stand on this decision. You may have one overriding reason to use or not use medicines.

Check the box below that represents your overall impression about your decision.

Return to the topic High Cholesterol.

Citations

1. Grundy SM, et al. (2004). Implications of recent clinical trials of the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation, 110(2): 227–239. [Erratum in Circulation, 110(6): 763.]

2. Foster C, et al. (2004). Primary prevention. Clinical Evidence (11): 163–195.

3. Pignone M, et al. (2004). Secondary prevention of ischaemic cardiac events. Clinical Evidence (12): 193–235.

4. Grundy SM, et al. (2001). Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA, 285(19): 2486–2497.

Author:	Robin Parks, MS	Last Updated: July 20, 2006
Medical Review:	E. Gregory Thompson, MD - Internal Medicine Robert A. Kloner, MD, PhD - Cardiology
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